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CD4+ and CD8+ T cells are considered distinct functional lymphocyte subsets. Cheroutre and Mucida and their colleagues show that mature gut-associated CD4+ T cells lose ThPOK expression and reactivate CD8 cytolytic effector programs.
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gut CD4 T cells can switch to CD8 cytotoxic. Nat Immunol 20 january 2013
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Nature Immunology 20 january 2013
Article by Mucida et al: http://www.nature.com/doifinder/10.1038/ni.2523
Article by Reis et al:http://www.nature.com/doifinder/10.1038/ni.2518
A summary of the findings at:
http://www.sciencedaily.com/releases/2013/01/130120145844.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fimmune_system+%28ScienceDaily%3A+Health+%26+Medicine+News+--+Immune+System%29&goback=.gde_2370476_member_206469340